New coronavirus variant: What do we know?

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<div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p><strong class="css-14iz86j-BoldText e5tfeyi0">The rapid spread of a new variant of coronavirus has been blamed for the introduction of strict tier four mixing rules for millions of people, harsher restrictions on mixing at Christmas in England, Scotland and Wales, and other countries placing the UK on a travel ban.</strong></p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>So how has it gone from being non-existent to the most common form of the virus in parts of England in a matter of months?</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>The government's advisers on new infections have "moderate" confidence that it is more able to transmit than other variants.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>All the work is at an early stage, contains huge uncertainties and a long list of unanswered questions.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>As I've written before, viruses mutate all the time and it's vital to keep a laser focus on whether the virus' behaviour is changing.</p> </div> </div> <div class="css-mysbf6-ComponentWrapper-CrossheadComponentWrapper e1xue1i84" data-component="crosshead-block"> <h2 class="css-qozapo-StyledHeading e1fj1fc10">Why is this variant causing concern?</h2> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>Three things are coming together that mean it is attracting attention:</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="unordered-list-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <div class="css-1pzprxn-BulletListContainer e5tfeyi3"> <ul> <li>It is rapidly replacing other versions of the virus</li> <li>It has mutations that affect part of the virus likely to be important</li> <li>Some of those mutations have already been shown in the lab to increase the ability of the virus to infect cells</li> </ul> </div> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>All of these come together to build a case for a virus that can spread more easily.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>However, we do not have absolute certainty. New strains can become more common simply by being in the right place at the right time - such as London, which had only tier two restrictions until recently.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>But already the justification for tier four restrictions is in part to reduce the spread of the variant.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>"Laboratory experiments are required, but do you want to wait weeks or months [to see the results and take action to limit the spread]? Probably not in these circumstances," Prof Nick Loman, from the Covid-19 Genomics UK Consortium, told me.</p> </div> </div> <div class="css-mysbf6-ComponentWrapper-CrossheadComponentWrapper e1xue1i84" data-component="crosshead-block"> <h2 class="css-qozapo-StyledHeading e1fj1fc10">How much faster is it spreading?</h2> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>It was first detected in September. In November around a quarter of cases in London were the new variant. This reached nearly two-thirds of cases in mid-December.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>You can see how the variant has come to dominate the results of testing in some centres such as the Milton Keynes Lighthouse Laboratory.</p> </div> </div> <div class="css-z0waap-ComponentWrapper-SocialEmbedComponentWrapper e1xue1i81" data-component="social-embed-block"> <div> <div class="twitter-tweet twitter-tweet-rendered"><iframe id="twitter-widget-2" class="" title="Twitter Tweet" src="https://platform.twitter.com/embed/index.html?creatorScreenName=BBCWorld&dnt=false&embedId=twitter-widget-2&frame=false&hideCard=false&hideThread=false&id=1340349639946629120&lang=en-gb&origin=https%3A%2F%2Fwww.bbc.com%2Fnews%2Fhealth-55388846&siteScreenName=BBCWorld&theme=light&widgetsVersion=ed20a2b%3A1601588405575&width=550px" width="300" height="150" frameborder="0" scrolling="no" allowfullscreen="allowfullscreen" data-tweet-id="1340349639946629120"></iframe></div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83">The BBC is not responsible for the content of external sites.View original tweet on Twitter</div> </div> <div class="css-18mjolk-ComponentWrapper e1xue1i80" data-component="image-block"> <figure class="css-2y05cd-StyledFigure e34k3c20"> <div class="css-kwaqyc-StyledFigureContainer e34k3c22"><span class="css-1rix78v-Placeholder e16icw910"><img class="css-evoj7m-Image ee0ct7c0" src="https://c.files.bbci.co.uk/604B/production/_97415642_007_in_numbers_624.png" srcset="https://ichef.bbci.co.uk/news/240/cpsprodpb/604B/production/_97415642_007_in_numbers_624.png 240w, https://ichef.bbci.co.uk/news/320/cpsprodpb/604B/production/_97415642_007_in_numbers_624.png 320w, https://ichef.bbci.co.uk/news/480/cpsprodpb/604B/production/_97415642_007_in_numbers_624.png 480w, https://ichef.bbci.co.uk/news/624/cpsprodpb/604B/production/_97415642_007_in_numbers_624.png 624w, https://ichef.bbci.co.uk/news/800/cpsprodpb/604B/production/_97415642_007_in_numbers_624.png 800w, https://ichef.bbci.co.uk/news/976/cpsprodpb/604B/production/_97415642_007_in_numbers_624.png 976w" alt="Presentational white space" width="624" height="1" /></span></div> </figure> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>Mathematicians have been running the numbers on the spread of different variants in an attempt to calculate how much of an edge this one might have.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>But teasing apart what is due to people's behaviour and what is due to the virus is hard.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>The figure mentioned by Prime Minister Boris Johnson was that the variant may be up to 70% more transmissible. He said this may be increasing the R number - which indicates if an epidemic is growing or shrinking - by 0.4.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>That 70% number appeared in a presentation by Dr Erik Volz, from Imperial College London, on Friday.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>During the talk he said: "It is really too early to tell… but from what we see so far it is growing very quickly, it is growing faster than [a previous variant] ever grew, but it is important to keep an eye on this."</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>There is no "nailed on" figure for how much more infectious the variant may be. Scientists, whose work is not yet public, have told me figures both much higher and much lower than 70%.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>But there remain questions about whether it is any more infectious at all.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>"The amount of evidence in the public domain is woefully inadequate to draw strong or firm opinions on whether the virus has truly increased transmission," said Prof Jonathan Ball, a virologist at the University of Nottingham.</p> </div> </div> <div class="css-mysbf6-ComponentWrapper-CrossheadComponentWrapper e1xue1i84" data-component="crosshead-block"> <h2 class="css-qozapo-StyledHeading e1fj1fc10">How far has it spread?</h2> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>It is thought the variant either emerged in a patient in the UK or has been imported from a country with a lower ability to monitor coronavirus mutations.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>The variant can be found across the UK, except Northern Ireland, but it is heavily concentrated in London, the South East and eastern England. Cases elsewhere in the country do not seem to have taken off.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>Data from Nextstrain, which has been monitoring the genetic codes of the viral samples around the world, suggest cases in Denmark and Australia have come from the UK. The Netherlands has also reported cases.</p> </div> </div> <div class="css-z0waap-ComponentWrapper-SocialEmbedComponentWrapper e1xue1i81" data-component="social-embed-block"> <div> <div class="twitter-tweet twitter-tweet-rendered"><iframe id="twitter-widget-3" class="" title="Twitter Tweet" src="https://platform.twitter.com/embed/index.html?creatorScreenName=BBCWorld&dnt=false&embedId=twitter-widget-3&frame=false&hideCard=false&hideThread=false&id=1340360004621230081&lang=en-gb&origin=https%3A%2F%2Fwww.bbc.com%2Fnews%2Fhealth-55388846&siteScreenName=BBCWorld&theme=light&widgetsVersion=ed20a2b%3A1601588405575&width=550px" width="300" height="150" frameborder="0" scrolling="no" allowfullscreen="allowfullscreen" data-tweet-id="1340360004621230081"></iframe></div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83">The BBC is not responsible for the content of external sites.View original tweet on Twitter</div> </div> <div class="css-18mjolk-ComponentWrapper e1xue1i80" data-component="image-block"> <figure class="css-2y05cd-StyledFigure e34k3c20"> <div class="css-kwaqyc-StyledFigureContainer e34k3c22"><span class="css-1rix78v-Placeholder e16icw910"><img class="css-evoj7m-Image ee0ct7c0" src="https://c.files.bbci.co.uk/604B/production/_97415642_007_in_numbers_624.png" srcset="https://ichef.bbci.co.uk/news/240/cpsprodpb/604B/production/_97415642_007_in_numbers_624.png 240w, https://ichef.bbci.co.uk/news/320/cpsprodpb/604B/production/_97415642_007_in_numbers_624.png 320w, https://ichef.bbci.co.uk/news/480/cpsprodpb/604B/production/_97415642_007_in_numbers_624.png 480w, https://ichef.bbci.co.uk/news/624/cpsprodpb/604B/production/_97415642_007_in_numbers_624.png 624w, https://ichef.bbci.co.uk/news/800/cpsprodpb/604B/production/_97415642_007_in_numbers_624.png 800w, https://ichef.bbci.co.uk/news/976/cpsprodpb/604B/production/_97415642_007_in_numbers_624.png 976w" alt="Presentational white space" width="624" height="1" /></span></div> </figure> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>A similar variant that has emerged in South Africa shares some of the same mutations, but appears to be unrelated to this one.</p> </div> </div> <div class="css-mysbf6-ComponentWrapper-CrossheadComponentWrapper e1xue1i84" data-component="crosshead-block"> <h2 class="css-qozapo-StyledHeading e1fj1fc10">Has this happened before?</h2> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>Yes.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>The virus that was first detected in Wuhan, China, is not the same one you will find in most corners of the world.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>The D614G mutation emerged in Europe in February and became the globally dominant form of the virus.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>Another, called A222V, spread across Europe and was linked to people's summer holidays in Spain.</p> </div> </div> <div class="css-mysbf6-ComponentWrapper-CrossheadComponentWrapper e1xue1i84" data-component="crosshead-block"> <h2 class="css-qozapo-StyledHeading e1fj1fc10">What do we know about the new mutations?</h2> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>An initial analysis of the new variant has been published and identifies 17 potentially important alterations.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>There have been changes to the spike protein - this is the key the virus uses to unlock the doorway to our body's cells.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>One mutation called N501Y alters the most important part of the spike, known as the "receptor-binding domain".</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>This is where the spike makes first contact with the surface of our body's cells. Any changes that make it easier for the virus to get inside are likely to give it an edge.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>"It looks and smells like an important adaptation," said Prof Loman.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>The other mutation - a H69/V70 deletion, in which a small part of the spike is removed - has emerged several times before, including famously in infected mink.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>Work by Prof Ravi Gupta at the University of Cambridge has suggested this mutation increases infectivity two-fold in lab experiments.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>Studies by the same group suggest the deletion makes antibodies from the blood of survivors less effective at attacking the virus.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>Prof Gupta told me: "It is rapidly increasing, that's what's worried government, we are worried, most scientists are worried."</p> </div> </div> <div class="css-mysbf6-ComponentWrapper-CrossheadComponentWrapper e1xue1i84" data-component="crosshead-block"> <h2 class="css-qozapo-StyledHeading e1fj1fc10">Where has it come from?</h2> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>The variant is unusually highly mutated.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>The most likely explanation is the variant has emerged in a patient with a weakened immune system that was unable to beat the virus.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>Instead their body became a breeding ground for the virus to mutate.</p> </div> </div> <div class="css-mysbf6-ComponentWrapper-CrossheadComponentWrapper e1xue1i84" data-component="crosshead-block"> <h2 class="css-qozapo-StyledHeading e1fj1fc10">Does it make the infection more deadly?</h2> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>There is no evidence to suggest that it does, although this will need to be monitored.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>However, just increasing transmission would be enough to cause problems for hospitals.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>If the new variant means more people are infected more quickly, that would in turn lead to more people needing hospital treatment.</p> </div> </div> <div class="css-mysbf6-ComponentWrapper-CrossheadComponentWrapper e1xue1i84" data-component="crosshead-block"> <h2 class="css-qozapo-StyledHeading e1fj1fc10">Will the vaccines work against the new variant?</h2> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>Almost certainly yes, or at least for now.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>All three leading vaccines develop an immune response against the existing spike, which is why the question comes up.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>Vaccines train the immune system to attack several different parts of the virus, so even though part of the spike has mutated, the vaccines should still work.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>"But if we let it add more mutations, then you start worrying," said Prof Gupta.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>"This virus is potentially on a pathway for vaccine escape, it has taken the first couple of steps towards that."</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>Vaccine escape happens when the virus changes so it dodges the full effect of the vaccine and continues to infect people.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>This may be the most concerning element of what is happening with the virus.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>This variant is just the latest to show the virus is continuing to adapt as it infects more and more of us.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>A presentation by Prof David Robertson, from the University of Glasgow on Friday, concluded: "The virus will probably be able to generate vaccine escape mutants."</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>That would put us in a position similar to flu, where the vaccines need to be regularly updated. Fortunately the vaccines we have are very easy to tweak.</p> </div> </div>
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<div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p><strong class="css-14iz86j-BoldText e5tfeyi0">The rapid spread of a new variant of coronavirus has been blamed for the introduction of strict tier four mixing rules for millions of people, harsher restrictions on mixing at Christmas in England, Scotland and Wales, and other countries placing the UK on a travel ban.</strong></p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>So how has it gone from being non-existent to the most common form of the virus in parts of England in a matter of months?</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>The government's advisers on new infections have "moderate" confidence that it is more able to transmit than other variants.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>All the work is at an early stage, contains huge uncertainties and a long list of unanswered questions.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>As I've written before, viruses mutate all the time and it's vital to keep a laser focus on whether the virus' behaviour is changing.</p> </div> </div> <div class="css-mysbf6-ComponentWrapper-CrossheadComponentWrapper e1xue1i84" data-component="crosshead-block"> <h2 class="css-qozapo-StyledHeading e1fj1fc10">Why is this variant causing concern?</h2> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>Three things are coming together that mean it is attracting attention:</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="unordered-list-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <div class="css-1pzprxn-BulletListContainer e5tfeyi3"> <ul> <li>It is rapidly replacing other versions of the virus</li> <li>It has mutations that affect part of the virus likely to be important</li> <li>Some of those mutations have already been shown in the lab to increase the ability of the virus to infect cells</li> </ul> </div> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>All of these come together to build a case for a virus that can spread more easily.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>However, we do not have absolute certainty. New strains can become more common simply by being in the right place at the right time - such as London, which had only tier two restrictions until recently.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>But already the justification for tier four restrictions is in part to reduce the spread of the variant.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>"Laboratory experiments are required, but do you want to wait weeks or months [to see the results and take action to limit the spread]? Probably not in these circumstances," Prof Nick Loman, from the Covid-19 Genomics UK Consortium, told me.</p> </div> </div> <div class="css-mysbf6-ComponentWrapper-CrossheadComponentWrapper e1xue1i84" data-component="crosshead-block"> <h2 class="css-qozapo-StyledHeading e1fj1fc10">How much faster is it spreading?</h2> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>It was first detected in September. In November around a quarter of cases in London were the new variant. This reached nearly two-thirds of cases in mid-December.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>You can see how the variant has come to dominate the results of testing in some centres such as the Milton Keynes Lighthouse Laboratory.</p> </div> </div> <div class="css-z0waap-ComponentWrapper-SocialEmbedComponentWrapper e1xue1i81" data-component="social-embed-block"> <div> <div class="twitter-tweet twitter-tweet-rendered"><iframe id="twitter-widget-2" class="" title="Twitter Tweet" src="https://platform.twitter.com/embed/index.html?creatorScreenName=BBCWorld&dnt=false&embedId=twitter-widget-2&frame=false&hideCard=false&hideThread=false&id=1340349639946629120&lang=en-gb&origin=https%3A%2F%2Fwww.bbc.com%2Fnews%2Fhealth-55388846&siteScreenName=BBCWorld&theme=light&widgetsVersion=ed20a2b%3A1601588405575&width=550px" width="300" height="150" frameborder="0" scrolling="no" allowfullscreen="allowfullscreen" data-tweet-id="1340349639946629120"></iframe></div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83">The BBC is not responsible for the content of external sites.View original tweet on Twitter</div> </div> <div class="css-18mjolk-ComponentWrapper e1xue1i80" data-component="image-block"> <figure class="css-2y05cd-StyledFigure e34k3c20"> <div class="css-kwaqyc-StyledFigureContainer e34k3c22"><span class="css-1rix78v-Placeholder e16icw910"><img class="css-evoj7m-Image ee0ct7c0" src="https://c.files.bbci.co.uk/604B/production/_97415642_007_in_numbers_624.png" srcset="https://ichef.bbci.co.uk/news/240/cpsprodpb/604B/production/_97415642_007_in_numbers_624.png 240w, https://ichef.bbci.co.uk/news/320/cpsprodpb/604B/production/_97415642_007_in_numbers_624.png 320w, https://ichef.bbci.co.uk/news/480/cpsprodpb/604B/production/_97415642_007_in_numbers_624.png 480w, https://ichef.bbci.co.uk/news/624/cpsprodpb/604B/production/_97415642_007_in_numbers_624.png 624w, https://ichef.bbci.co.uk/news/800/cpsprodpb/604B/production/_97415642_007_in_numbers_624.png 800w, https://ichef.bbci.co.uk/news/976/cpsprodpb/604B/production/_97415642_007_in_numbers_624.png 976w" alt="Presentational white space" width="624" height="1" /></span></div> </figure> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>Mathematicians have been running the numbers on the spread of different variants in an attempt to calculate how much of an edge this one might have.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>But teasing apart what is due to people's behaviour and what is due to the virus is hard.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>The figure mentioned by Prime Minister Boris Johnson was that the variant may be up to 70% more transmissible. He said this may be increasing the R number - which indicates if an epidemic is growing or shrinking - by 0.4.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>That 70% number appeared in a presentation by Dr Erik Volz, from Imperial College London, on Friday.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>During the talk he said: "It is really too early to tell… but from what we see so far it is growing very quickly, it is growing faster than [a previous variant] ever grew, but it is important to keep an eye on this."</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>There is no "nailed on" figure for how much more infectious the variant may be. Scientists, whose work is not yet public, have told me figures both much higher and much lower than 70%.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>But there remain questions about whether it is any more infectious at all.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>"The amount of evidence in the public domain is woefully inadequate to draw strong or firm opinions on whether the virus has truly increased transmission," said Prof Jonathan Ball, a virologist at the University of Nottingham.</p> </div> </div> <div class="css-mysbf6-ComponentWrapper-CrossheadComponentWrapper e1xue1i84" data-component="crosshead-block"> <h2 class="css-qozapo-StyledHeading e1fj1fc10">How far has it spread?</h2> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>It is thought the variant either emerged in a patient in the UK or has been imported from a country with a lower ability to monitor coronavirus mutations.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>The variant can be found across the UK, except Northern Ireland, but it is heavily concentrated in London, the South East and eastern England. Cases elsewhere in the country do not seem to have taken off.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>Data from Nextstrain, which has been monitoring the genetic codes of the viral samples around the world, suggest cases in Denmark and Australia have come from the UK. The Netherlands has also reported cases.</p> </div> </div> <div class="css-z0waap-ComponentWrapper-SocialEmbedComponentWrapper e1xue1i81" data-component="social-embed-block"> <div> <div class="twitter-tweet twitter-tweet-rendered"><iframe id="twitter-widget-3" class="" title="Twitter Tweet" src="https://platform.twitter.com/embed/index.html?creatorScreenName=BBCWorld&dnt=false&embedId=twitter-widget-3&frame=false&hideCard=false&hideThread=false&id=1340360004621230081&lang=en-gb&origin=https%3A%2F%2Fwww.bbc.com%2Fnews%2Fhealth-55388846&siteScreenName=BBCWorld&theme=light&widgetsVersion=ed20a2b%3A1601588405575&width=550px" width="300" height="150" frameborder="0" scrolling="no" allowfullscreen="allowfullscreen" data-tweet-id="1340360004621230081"></iframe></div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83">The BBC is not responsible for the content of external sites.View original tweet on Twitter</div> </div> <div class="css-18mjolk-ComponentWrapper e1xue1i80" data-component="image-block"> <figure class="css-2y05cd-StyledFigure e34k3c20"> <div class="css-kwaqyc-StyledFigureContainer e34k3c22"><span class="css-1rix78v-Placeholder e16icw910"><img class="css-evoj7m-Image ee0ct7c0" src="https://c.files.bbci.co.uk/604B/production/_97415642_007_in_numbers_624.png" srcset="https://ichef.bbci.co.uk/news/240/cpsprodpb/604B/production/_97415642_007_in_numbers_624.png 240w, https://ichef.bbci.co.uk/news/320/cpsprodpb/604B/production/_97415642_007_in_numbers_624.png 320w, https://ichef.bbci.co.uk/news/480/cpsprodpb/604B/production/_97415642_007_in_numbers_624.png 480w, https://ichef.bbci.co.uk/news/624/cpsprodpb/604B/production/_97415642_007_in_numbers_624.png 624w, https://ichef.bbci.co.uk/news/800/cpsprodpb/604B/production/_97415642_007_in_numbers_624.png 800w, https://ichef.bbci.co.uk/news/976/cpsprodpb/604B/production/_97415642_007_in_numbers_624.png 976w" alt="Presentational white space" width="624" height="1" /></span></div> </figure> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>A similar variant that has emerged in South Africa shares some of the same mutations, but appears to be unrelated to this one.</p> </div> </div> <div class="css-mysbf6-ComponentWrapper-CrossheadComponentWrapper e1xue1i84" data-component="crosshead-block"> <h2 class="css-qozapo-StyledHeading e1fj1fc10">Has this happened before?</h2> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>Yes.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>The virus that was first detected in Wuhan, China, is not the same one you will find in most corners of the world.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>The D614G mutation emerged in Europe in February and became the globally dominant form of the virus.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>Another, called A222V, spread across Europe and was linked to people's summer holidays in Spain.</p> </div> </div> <div class="css-mysbf6-ComponentWrapper-CrossheadComponentWrapper e1xue1i84" data-component="crosshead-block"> <h2 class="css-qozapo-StyledHeading e1fj1fc10">What do we know about the new mutations?</h2> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>An initial analysis of the new variant has been published and identifies 17 potentially important alterations.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>There have been changes to the spike protein - this is the key the virus uses to unlock the doorway to our body's cells.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>One mutation called N501Y alters the most important part of the spike, known as the "receptor-binding domain".</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>This is where the spike makes first contact with the surface of our body's cells. Any changes that make it easier for the virus to get inside are likely to give it an edge.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>"It looks and smells like an important adaptation," said Prof Loman.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>The other mutation - a H69/V70 deletion, in which a small part of the spike is removed - has emerged several times before, including famously in infected mink.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>Work by Prof Ravi Gupta at the University of Cambridge has suggested this mutation increases infectivity two-fold in lab experiments.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>Studies by the same group suggest the deletion makes antibodies from the blood of survivors less effective at attacking the virus.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>Prof Gupta told me: "It is rapidly increasing, that's what's worried government, we are worried, most scientists are worried."</p> </div> </div> <div class="css-mysbf6-ComponentWrapper-CrossheadComponentWrapper e1xue1i84" data-component="crosshead-block"> <h2 class="css-qozapo-StyledHeading e1fj1fc10">Where has it come from?</h2> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>The variant is unusually highly mutated.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>The most likely explanation is the variant has emerged in a patient with a weakened immune system that was unable to beat the virus.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>Instead their body became a breeding ground for the virus to mutate.</p> </div> </div> <div class="css-mysbf6-ComponentWrapper-CrossheadComponentWrapper e1xue1i84" data-component="crosshead-block"> <h2 class="css-qozapo-StyledHeading e1fj1fc10">Does it make the infection more deadly?</h2> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>There is no evidence to suggest that it does, although this will need to be monitored.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>However, just increasing transmission would be enough to cause problems for hospitals.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>If the new variant means more people are infected more quickly, that would in turn lead to more people needing hospital treatment.</p> </div> </div> <div class="css-mysbf6-ComponentWrapper-CrossheadComponentWrapper e1xue1i84" data-component="crosshead-block"> <h2 class="css-qozapo-StyledHeading e1fj1fc10">Will the vaccines work against the new variant?</h2> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>Almost certainly yes, or at least for now.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>All three leading vaccines develop an immune response against the existing spike, which is why the question comes up.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>Vaccines train the immune system to attack several different parts of the virus, so even though part of the spike has mutated, the vaccines should still work.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>"But if we let it add more mutations, then you start worrying," said Prof Gupta.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>"This virus is potentially on a pathway for vaccine escape, it has taken the first couple of steps towards that."</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>Vaccine escape happens when the virus changes so it dodges the full effect of the vaccine and continues to infect people.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>This may be the most concerning element of what is happening with the virus.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>This variant is just the latest to show the virus is continuing to adapt as it infects more and more of us.</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>A presentation by Prof David Robertson, from the University of Glasgow on Friday, concluded: "The virus will probably be able to generate vaccine escape mutants."</p> </div> </div> <div class="css-uf6wea-RichTextComponentWrapper e1xue1i83" data-component="text-block"> <div class="css-83cqas-RichTextContainer e5tfeyi2"> <p>That would put us in a position similar to flu, where the vaccines need to be regularly updated. Fortunately the vaccines we have are very easy to tweak.</p> </div> </div>
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